What does Isabela mean?
A Spanish form of Isabel, which arose in medieval Iberia and Provence as a variant of Elizabeth, from the Hebrew Elisheva 'my God is an oath' (or 'God is abundance'). It became a royal name in Spain, Portugal and England.
What does Reina mean?
The Spanish word 'reina' means 'queen', descending from Latin 'regina'. Also spelled Reyna. (A separate Hebrew/Yiddish name Reina meaning 'pure' exists; the Spanish 'queen' sense is the relevant one here.)